Yazar "Ayaz-Guner, Serife" için listeleme
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A comparative study on normal and obese mice indicates that the secretome of mesenchymal stromal cells is influenced by tissue environment and physiopathological conditions
Ayaz-Guner, Serife; Alessio, Nicola; Acar, Mustafa B.; Aprile, Domenico; Ozcan, Servet; Di Bernardo, Giovanni; Peluso, Gianfranco; Galderisi, Umberto (BMC, CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND, 2020)Background: The term mesenchymal stromal cells (MSCs) designates an assorted cell population comprised of stem cells, progenitor cells, fibroblasts, and stromal cells. MSCs contribute to the homeostatic maintenance of many ... -
Improved senescent cell segmentation on bright-field microscopy images exploiting representation level contrastive learning
Çelebi, Fatma; Boyvat, Dudu; Ayaz-Guner, Serife; Tasdemir, Kasim; Icoz, Kutay (WILEY Online Library, 2024)Mesenchymal stem cells (MSCs) are stromal cells which have multi-lineage differentiation and self-renewal potentials. Accurate estimation of total number of senescent cells in MSCs is crucial for clinical applications. ... -
An integrative-omics analysis of an industrial clavulanic acid-overproducing Streptomyces clavuligerus
Kurt Kızıldoğan, Aslıhan; Çelik, Gözde; Ünsaldı, Eser; Özcan, Servet; Ayaz-Guner, Serife; Özcengiz, Gülay (Springer, 2022)Clavulanic acid (CA) is a clinically important secondary metabolite used to treat infectious diseases. We aimed to decipher complex regulatory mechanisms acting in CA biosynthesis by analyzing transcriptome- and proteome-wide ... -
Proteomic and Biological Analysis of the Effects of Metformin Senomorphics on the Mesenchymal Stromal Cells
Acar, Mustafa Burak; Ayaz-Guner, Serife; Gunaydin, Zeynep; Karakukcu, Musa; Peluso, Gianfranco; Di Bernardo, Giovanni; Ozcan, Servet; Galderisi, Umberto (FRONTIERS MEDIA SAAVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE CH-1015, SWITZERLAND, 2021)Senotherapeutics are new drugs that can modulate senescence phenomena within tissues and reduce the onset of age-related pathologies. Senotherapeutics are divided into senolytics and senomorphics. The senolytics selectively ... -
Proteomic fertility markers in ram sperm
Hitit, Mustafa; Ozbek, Mehmet; Ayaz-Guner, Serife; Guner, Huseyin; Oztug, Merve; Bodu, Mustafa; Kirbas, Mesut; Bulbul, Bulent; Bucak, Mustafa Numan; Ataman, Mehmet Bozkurt; Memili, Erdogan; Kaya, Abdullah (ELSEVIERRADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS, 2021)Precise estimation of ram fertility is important for sheep farming to sustain reproduction efficiency and profitability of production. There, however, is no conventional method to accurately predict ram fertility. The ... -
Protocol for cell surface biotinylation of magnetic labeled and captured human peripheral blood mononuclear cells
Ayaz-Guner, Serife; Acar, Mustafa Burak; Boyvat, Dudu; Guner, Huseyin; Bozalan, Habibe; Güzel, Melis; Yıldır, Selin Kübra; Altınsoy, Nilay; Fındık, Fatma; Karakükçü, Musa; Özcan, Servet (Cell Press, 2022)Analysis of the surfaceome of a blood cell subset requires cell sorting, followed by surface protein enrichment. Here, we present a protocol combining magnetically activated cell sorting (MACS) and surface biotinylation ... -
A subtractive proteomics approach for the identification of immunodominant Acinetobacter baumannii vaccine candidate proteins
Acar, Mustafa Burak; Ayaz-Guner, Serife; Guner, Huseyin; Dinc, Gokcen; Kilic, Aysegul Ulu; Doganay, Mehmet; Ozcan, Servet (FRONTIERS MEDIA SA, 2022)Background: Acinetobacter baumannii is one of the most life-threatening multidrug-resistant pathogens worldwide. Currently, 50%–70% of clinical isolates of A. baumannii are extensively drug-resistant, and available antibiotic ... -
Why Do Muse Stem Cells Present an Enduring Stress Capacity? Hints from a Comparative Proteome Analysis
Acar, Mustafa B.; Aprile, Domenico; Ayaz-Guner, Serife; Guner, Huseyin; Tez, Coskun; Di Bernardo, Giovanni; Peluso, Gianfranco; Ozcan, Servet; Galderisi, Umberto (MDPIST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND, 2021)Muse cells are adult stem cells that are present in the stroma of several organs and possess an enduring capacity to cope with endogenous and exogenous genotoxic stress. In cell therapy, the peculiar biological properties ...
