Yazar "Güner, Hüseyin" için listeleme
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Biochemical, pharmacological, and toxicological attributes of caper (Capparis ovata) flowering buds and berries pickles
Ozgun-Acar, Ozden; Celik-Turgut, Gurbet; Guner, Huseyin; Sezer, Serdar; Sen, Alaattin (WILEY, 2022)Capparis ovata is a natural plant that grows widely in Turkey and its flowering buds and berry pickle are used in traditional medicine. Thus, the current study was expanded to evaluate the biochemical, pharmacological, ... -
Dual Targeting of DNA Damage Response Proteins Implicated in Cancer Radioresistance
Vasilopoulos, Spyridon N.; Güner, Hüseyin; Uça Apaydın, Merve; Pavlopoulou, , Athanasia; Georgakilas, Alexandros G. (Multidisciplinary Digital Publishing Institute (MDPI), 2023)Ionizing radiation can induce different types of DNA lesions, leading to genomic instability and ultimately cell death. Radiation therapy or radiotherapy, a major modality in cancer treatment, harnesses the genotoxic ... -
Molecular recognition of protein-ligand complexes via convolutional neural networks
Güner, Hüseyin (Abdullah Gül Üniversitesi Fen Bilimleri Enstitüsü, 2022)As a sub-discipline of Artificial Intelligence, deep neural networks have received enormous interest in research and industrial applications over the last decades owing to their highly successful performance in addressing ... -
Synthesis and Comprehensive in Vivo Activity Profiling of Olean-12-en-28-ol, 3β-Pentacosanoate in Experimental Autoimmune Encephalomyelitis: A Natural Remyelinating and Anti-Inflammatory Agent
Senol, Halil; Ozgun-Acar, Ozden; Daǧ, Aydan; Eken, Ahmet; Guner, Hüseyin; Aykut, Zaliha Gamze; Topcu, Gulacti; Sen, Alaattin (American Chemical Society(ACM), 2023)Multiple sclerosis (MS) treatment has received much attention, yet there is still no certain cure. We herein investigate the therapeutic effect of olean-12-en-28-ol, 3β-pentacosanoate (OPCA) on a preclinical model of MS. ... -
TRAIL promotes the polarization of human macrophages toward a proinflammatory M1 phenotype and is associated with increased survival in cancer patients with high tumor macrophage content
Gunalp, Sinem; Helvaci, Derya Goksu; Oner, Aysenur; Bursalı, Ahmet; Conforte, Alessandra; Güner, Hüseyin; Karakülah, Gökhan; Szegezdi, Eva; Sag, Duygu (FRONTIERS MEDIA SA, 2023)BackgroundTNF-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can either induce cell death or activate survival pathways after binding to death receptors (DRs) DR4 or DR5. TRAIL is ...
