Browsing by Department "AGÜ, Fen Bilimleri Enstitüsü, Biyomühendislik Ana Bilim Dalı"
Now showing items 1-9 of 9
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A BIOMIMETIC APPROACH FOR SMALL DIAMETER VESSELS: BILAYERED VASCULAR GRAFTS MADE of ALGINATE and POLY(-CAPROLACTONE)
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2019)Cardiovascular diseases (CVDs) still remain one of the leading causes of morbidity and mortality across the world. A typical symptom of CVDs is the vascular occlusion. There are many strategies for treatment such as ... -
CHARACTERIZATION OF NOVEL CILIARY GENE TMEM145
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2020)Cilia and flagella are highly conserved, microtubule based cellular structures which are found in most of the organisms. They have variety of functions from enabling movement in protozoa to signal transduction in multi ... -
DEVELOPMENT OF A KIDNEY TARGETTED NANOCARRIER FORMULATION AGAINST CISPLATIN INDUCED NEPHROTOXICITY
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2019)Chitosan is a natural polymer which is less toxic in the body than other synthetic polymers. Chitosan sodium tripolyphosphate (TPP) nanoparticles produced by ionic gelation method are known to be good drug delivery agents ... -
DEVELOPMENT OF A LOW-COST MICROFLUIDIC SYSTEM TO DETECT IMMUNOMAGNETICALLY CAPTURED LEUKEMIA CELLS
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2020)Sensör teknolojileri fiziksel özellikleri ölçülebilir sinyallere dönüştürmek için kullanılır. Özellikle yarı iletken teknolojisindeki gelişmelerle birlikte, mikroakışkan olarak bilinen yeni bir teknoloji ortaya çıktı. ... -
THE EFFECT OF HISTONE DEACETYLASE INHIBITORS ON PTEN/PI3K/AKT/mTOR PATHWAY AND THE CARCINOGENESIS OF CHEMORESISTANT CHOLANGIOCARCINOMA AT A MOLECULAR LEVEL
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2021)Kolanjiokarsinom (CCA) agresif bir adenokarsinomdur ve ikinci en sık görülen birincil karaciğer tümörüdür. CCA gelişiminin kesin etiyolojisi hala net olarak tanımlanmamıştır. Mevcut kemoterapötik tedaviler, çoklu ilaç ... -
The inhibition of autophagy and hedgehog pathway leads to a decrease in the proliferation of cholangiocarcinoma
(Abdullah Gül Üniversitesi, 2019)Cholangiocarcinoma (CCA) is the second most common liver cancer type. The median survival rate of CCA patients is really low. Aberrant signaling pathways such as PI3K/AKT/mTOR pathway could be main drivers in CCA pathogenesis. ... -
INVESTIGATION OF NEW CILIOPATHY GENES
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2021)Kirpikler, iç yapısında mikrotübüllerden oluşur ve evrimsel olarak anten benzeri bir organel korunmuştur. Kirpik yapısındaki bozuklukların neden olduğu hastalığa siliyopati adı verilir ve Joubert sendromu siliyopatilerden ... -
THE ROLE OF CERAMIDE METABOLISM IN APOPTOSIS TRIGGERED BY RESVERATROL AND THE THERAPEUTIC POTENTIAL OF RESVERATROL IN PH+ ACUTE LYMPHOBLASTIC LEUKEMIA
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2019)The mechanisms underlying the growth inhibitory effect of resveratrol on Ph + ALL cells were investigated with regard to targeting of ceramide metabolism and changes in BCR-ABL expression. Growth inhibition and apoptotic ... -
THERAPEUTIC POTENTIAL OF RESVERATROL AND THE ROLE OF CERAMIDE METABOLISM IN RESVERATROL-TRIGGERED APOPTOSIS IN FLT3+ ACUTE MYELOID LEUKEMIA
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2021)Resveratrol’ün FLT3-ITD+ AML hücreleri üzerindeki büyüme engelleyici etkilerinin altında yatan mekanizmalar, seramid metabolizması hedeflenerek araştırıldı. Resveratrol, SK (sfingosin kinaz) inhibitörü (SKI II), GCS ...
