Browsing by Author "Topuzogullari, Murat"
Now showing items 1-7 of 7
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Core-crosslinking as a pathway to develop inherently antibacterial polymeric micelles
Kadayifci, Melike Seyma; Gokkaya, Damla; Topuzogullari, Murat; Isoglu, Sevil Dincer; Atabey, Tugba; Arasoglu, Tulin; Ozmen, Mehmet Murat (WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2019)Positively charged polymeric materials have been an alternative to combat bacteria as they exhibit inherently antibacterial potency via bacteria membrane disruption. In this study, we report facile preparation of positively ... -
HER2-Targeted, Degradable Core Cross-Linked Micelles for Specific and Dual pH-Sensitive DOX Release
Bayram, Nazende Nur; Ulu, Gizem Tugce; Topuzogullari, Murat; Baran, Yusuf; Isoglu, Sevil Dincer (WILEY-V C H VERLAG GMBHPOSTFACH 101161, 69451 WEINHEIM, GERMANY, 2021)Here, a targeted, dual-pH responsive, and stable micelle nanocarrier is designed, which specifically selects an HER2 receptor on breast cancer cells. Intracellularly degradable and stabilized micelles are prepared by core ... -
Microwave-assisted green approach for graft copolymerization of l-lactic acid onto starch
Salimi, Kouroush; Topuzogullari, Murat; Dincer, Sevil; Aydin, Halil Murat (WILEY111 RIVER ST, HOBOKEN 07030-5774, NJ, 2016)Poly l-lactic acid grafted starch (St-g-PLA) copolymers were directly synthesized under microwave irradiation by using sodium hydroxide (NaOH) and stannous 2-ethyl hexanoate acting as a catalyst, without the use of toxic ... -
A new approach for development of vaccine against visceral leishmaniasis: Lipophosphoglycan and polyacrylic acid conjugates
Allahverdiyev, Adil M.; Koc, Rabia Cakir; Bagirova, Melahat; Elcicek, Serhat; Yesilkir Baydar, Serap; Oztel, Olga Nehir; Abamor, Emrah Sefik; Ates, Sezen Canim; Topuzogullari, Murat; Dincer, Sevil Isoglu; Akdeste, Zeynep (ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND, 2017)Objective: To determine the antileishmanial vaccine effectiveness of lipophosphoglycan (LPG) and polyacrylic acids (PAA) conjugates on in vivo mice models. Methods: LPG molecule was isolated and purified from large-scale ... -
pH- and temperature-responsive amphiphilic diblock copolymers of 4-vinylpyridine and oligoethyleneglycol methacrylate synthesized by RAFT polymerization
Topuzogullari, Murat; Bulmus, Volga; Dalgakiran, Eray; Dincer, Sevil (ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND, 2014)Diblock copolymers of 4-vinylpyridine (4VP) and oligoethyleneglycol methyl ether methacrylate (OEGMA) were synthesized for the first time using RAFT polymerization technique as potential drug delivery systems. Effects of ... -
RAFT-synthesized POEGMA-b-P4VP block copolymers: preparation of nanosized micelles for anticancer drug release
Bayram, Nazende Nur; Topuzogullari, Murat; Isoglu, Ismail Alper; Isoglu, Sevil Dincer (SPRINGERONE NEW YORK PLAZA, SUITE 4600 , NEW YORK, NY 10004, UNITED STATES, 2021)To achieve high stability and biocompatibility in physiological environment, oligoethyleneglycol methacrylate (OEGMA) and 4-vinylpyridine (4VP)-based amphiphilic block copolymers were prepared as micellar carriers to deliver ... -
Thermo-Responsive Complexes of c-Myc Antisense Oligonucleotide with Block Copolymer of Poly(OEGMA) and Quaternized Poly(4-Vinylpyridine)
Topuzogullari, Murat; Elalmis, Yeliz Basaran; Isoglu, Sevil Dincer (WILEY-V C H VERLAG GMBHPOSTFACH 101161, 69451 WEINHEIM, GERMANY, 2017)Solution behavior of thermo-responsive polymers and their complexes with biological macromolecules may be affected by environmental conditions, such as the concentration of macromolecular components, pH, ion concentration, ...
