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dc.contributor.authorIsoglu, Ismail Alper
dc.contributor.authorSonmezer, Dilek
dc.contributor.authorLatifoglu, Fatma
dc.contributor.authorToprak, Guler
dc.contributor.authorDuzler, Ayhan
dc.date.accessioned2022-02-24T10:48:02Z
dc.date.available2022-02-24T10:48:02Z
dc.date.issued2021en_US
dc.identifier.issn0959-2989
dc.identifier.issn1878-3619
dc.identifier.otherPubMed ID33682690
dc.identifier.urihttps //doi.org/10.3233/BME-196014
dc.identifier.urihttps://hdl.handle.net/20.500.12573/1179
dc.descriptionThis work was supported by the Scientific Research Projects Unit of Erciyes University with the project ONAP, FOA-2016-6692, Turkey.en_US
dc.description.abstractBACKGROUND: The heart is surrounded by a membrane called pericardium or pericardial cavity. OBJECTIVE: In this study, we investigated the pericardial fluid (PF) for coating polycaprolactone (PCL) scaffolds. PFS, which is a PF component, was used for the coating material. In addition to using PFS for surface coating, MED and fetal bovine serum (FBS) were also used for comparison. METHODS: Pericardial fluid cells (PFSc) isolated from PF were cultured on coated PCL scaffolds for 1, 3, and 5 days. Cell viability was determined using 3-(4, 5-di-methylthiazol- 2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. RESULTS: The MTT assay results showed that the viability of cells on PCL scaffold coated with PFS increased over time (P < 0.005), and cell viability was significantly different between PCL scaffolds coated with PFS and non-coated PCL scaffolds. However, cell viability was significantly higher in the PCL scaffolds coated with PFS than non-coated and coated with FBS, MED, and PCL scaffolds. Scanning electron microscopy (SEM) microscopy images and MTT assay indicated that PFSc are attached, proliferated, and spread on PCL scaffolds, especially on PCL scaffolds coated with PFS. CONCLUSIONS: These results suggest that PFS is a biocompatible material for surface modification of PCL scaffolds, which can be used as a suitable material for tissue engineering applications.en_US
dc.description.sponsorshipErciyes University FOA-2016-6692en_US
dc.language.isoengen_US
dc.publisherIOS PRESSNIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDSen_US
dc.relation.isversionof10.3233/BME-196014en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPericardial fluid (PF)en_US
dc.subjectpolycaprolactone (PCL)en_US
dc.subjectpericardial fluid structureen_US
dc.subjecttissue engineeringen_US
dc.titlePericardial fluid and vascular tissue engineering: A preliminary studyen_US
dc.typearticleen_US
dc.contributor.departmentAGÜ, Mühendislik Fakültesi, Malzeme Bilimi ve Nanoteknoloji Mühendisliği Bölümüen_US
dc.contributor.institutionauthorIsoglu, Ismail Alper
dc.identifier.volumeVolume 32 Issue 2 Page 101-113en_US
dc.relation.journalBIO-MEDICAL MATERIALS AND ENGINEERINGen_US
dc.relation.publicationcategoryMakale - Uluslararası - Editör Denetimli Dergien_US


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