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dc.contributor.authorSeymen, A. A.
dc.contributor.authorOzgur, E.
dc.contributor.authorSoran-Erdem, Z.
dc.contributor.authorOrtac, B.
dc.date.accessioned2022-03-01T07:25:35Z
dc.date.available2022-03-01T07:25:35Z
dc.date.issued2021en_US
dc.identifier.issn1041-1135
dc.identifier.issn1941-0174
dc.identifier.urihttps //doi.org/10.1109/LPT.2021.3049348
dc.identifier.urihttps://hdl.handle.net/20.500.12573/1203
dc.descriptionThis work was supported by the Ministry of Science, Industry, and Technology of Turkey.en_US
dc.description.abstractPatch-clamp technique is the gold standard for cellular electrophysiological measurements, which is capable of measuring single ion transport events across the cell membrane. However, the measurement possesses significant complexities, and it requires a high level of expertise, while its experimental throughput is nevertheless considerably low. Here, we suggest and experimentally demonstrate a laser-assisted method for performing cellular electrophysiological measurements. Femtosecond laser pulses, coupled to an optical microscope, are used to form a sub-micrometer hole on a thin polymer membrane separating two electrodes, where a nearby cell is subsequently placed onto the hole by negative pressure. Afterwards, the cell is punctured using subsequent laser exposure, revealing the cell membrane over the hole for electrophysiological recording. This system could be used to increase the output amount of the electrophysiological measurements substantially.en_US
dc.description.sponsorshipMinistry of Science, Industry & Technology - Turkeyen_US
dc.language.isoengen_US
dc.publisherIEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC445 HOES LANE, PISCATAWAY, NJ 08855-4141en_US
dc.relation.isversionof10.1109/LPT.2021.3049348en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIonsen_US
dc.subjectElectrodesen_US
dc.subjectUltrafast opticsen_US
dc.subjectLasersen_US
dc.subjectElectrophysiologyen_US
dc.subjectMeasurement by laser beamen_US
dc.subjectNanotechnologyen_US
dc.subjectLaser nanosurgeryen_US
dc.subjectfemtosecond laseren_US
dc.subjectelectrophysiologyen_US
dc.titleA Laser-Assisted Cellular Electrophysiology Measurement Systemen_US
dc.typearticleen_US
dc.contributor.departmentAGÜ, Mühendislik Fakültesi, Mühendislik Bilimleri Bölümüen_US
dc.contributor.authorID0000-0001-7607-9286en_US
dc.contributor.institutionauthorSoran-, Erdem, Z.
dc.identifier.volumeVolume 33 Issue 3 Page 163-166en_US
dc.relation.journalIEEE PHOTONICS TECHNOLOGY LETTERSen_US
dc.relation.publicationcategoryMakale - Uluslararası - Editör Denetimli Dergien_US


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