dc.contributor.author | Ebrahimi, Aliakbar | |
dc.contributor.author | Icoz, Kutay | |
dc.contributor.author | Didarian, Reza | |
dc.contributor.author | Shih, Chih-Hsin | |
dc.contributor.author | Tarim, E. Alperay | |
dc.contributor.author | Nasseri, Behzad | |
dc.contributor.author | Akpek, Ali | |
dc.contributor.author | Cecen, Berivan | |
dc.contributor.author | Bal-Ozturk, Ayca | |
dc.contributor.author | Güleç, Kadri | |
dc.contributor.author | Li, Yi-Chen Ethan | |
dc.contributor.author | Shih, Steven | |
dc.contributor.author | Sirma Tarim, Burcu | |
dc.contributor.author | Tekin, H. Cumhur | |
dc.contributor.author | Tayybi-Azar, Mehdi | |
dc.contributor.author | Ghorbanpoor, Hamed | |
dc.contributor.author | Özel, Ceren | |
dc.contributor.author | Eker Sarıboyacı, Ayla | |
dc.contributor.author | Dogan Guzel, Fatma | |
dc.contributor.author | Bassous, Nicole | |
dc.contributor.author | Shin, Su Ryon | |
dc.contributor.author | Avci, Huseyin | |
dc.contributor.author | Alarçin, Emine | |
dc.date.accessioned | 2024-03-05T13:02:33Z | |
dc.date.available | 2024-03-05T13:02:33Z | |
dc.date.issued | 2024 | en_US |
dc.identifier.issn | 2196-7350 | |
dc.identifier.uri | https://doi.org/10.1002/admi.202300492 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12573/1985 | |
dc.description.abstract | Separation and identification of molecules and biomolecules such as nucleic acids, proteins, and polysaccharides from complex fluids are known to be important due to unmet needs in various applications. Generally, many different separation techniques, including chromatography, electrophoresis, and magnetophoresis, have been developed to identify the target molecules precisely. However, these techniques are expensive and time consuming. “Lab-on-a-chip” systems with low cost per device, quick analysis capabilities, and minimal sample consumption seem to be ideal candidates for separating particles, cells, blood samples, and molecules. From this perspective, different microfluidic-based techniques have been extensively developed in the past two decades to separate samples with different origins. In this review, “lab-on-a-chip” methods by passive, active, and hybrid approaches for the separation of biomolecules developed in the past decade are comprehensively discussed. Due to the wide variety in the field, it will be impossible to cover every facet of the subject. Therefore, this review paper covers passive and active methods generally used for biomolecule separation. Then, an investigation of the combined sophisticated methods is highlighted. The spotlight also will be shined on the elegance of separation successes in recent years, and the remainder of the article explores how these permit the development of novel techniques. | en_US |
dc.description.sponsorship | This study was supported by the Turkish Scientific and Technological Council (TÜBITAK) under the grant numbers of 119N608. Y.C.E.L. would like to thank the Ministry of Science and Technology, Taiwan (MOST 109-2221-E035-036-MY3, and MOST 110-2124-M-005-001-MY3), for supporting this work. H.C.T. acknowledges financial support from The Scientific and Technological Research Council of Turkey (grant number 119M052). H.C.T. would like to thank Outstanding Young Scientists Award funding (TUBAGEBIP 2020) from the Turkish Academy of Science. E.A.T. and C.Ö. acknowledge the support of The Scientific and Technological Research Council of Turkey for 2211-A BIDEB doctoral scholarship, and Turkish Council of Higher Education for 100/2000 CoHE doctoral scholarship. H.G. would like to thank The Scientific and Technological Research Council of Turkey
(grant number 222M468) for supporting this work. This study was supported by Turkish Scientific and Technological Council
(TUBITAK 1004- Regenerative and Restorative Medicine Research and Applications) under the grant numbers of 20AG003 and 20AG031 and Scientific Research Projects (BAP- the priority areas project (ONAP) under the grant number
of TOA-2022-2307 and TYL-2023-2720 of Eskisehir Osmangazi University. This study was supported by Yildiz Technical University Scientific Research Projects with the project number TSA-2022-5317. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | John Wiley and Sons Inc | en_US |
dc.relation.isversionof | 10.1002/admi.202300492 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | active separation | en_US |
dc.subject | biomolecule separation | en_US |
dc.subject | hybrid separation | en_US |
dc.subject | lab-on-achip | en_US |
dc.subject | microfluidics | en_US |
dc.subject | passive separation | en_US |
dc.title | Molecular Separation by Using Active and Passive Microfluidic chip Designs: A Comprehensive Review | en_US |
dc.type | article | en_US |
dc.contributor.department | AGÜ, Mühendislik Fakültesi, Malzeme Bilimi ve Nanoteknoloji Mühendisliği Bölümü | en_US |
dc.contributor.authorID | 0000-0002-0947-6166 | en_US |
dc.contributor.institutionauthor | Icoz, Kutay | |
dc.identifier.volume | 11 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 1 | en_US |
dc.identifier.endpage | 45 | en_US |
dc.relation.journal | Advanced Materials Interfaces | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |