Yazar "0000-0002-8444-376X" için Moleküler Biyoloji ve Genetik Bölümü Koleksiyonu listeleme
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Biochemical, pharmacological, and toxicological attributes of caper (Capparis ovata) flowering buds and berries pickles
Ozgun-Acar, Ozden; Celik-Turgut, Gurbet; Guner, Huseyin; Sezer, Serdar; Sen, Alaattin (WILEY, 2022)Capparis ovata is a natural plant that grows widely in Turkey and its flowering buds and berry pickle are used in traditional medicine. Thus, the current study was expanded to evaluate the biochemical, pharmacological, ... -
Complementary medicines used in ulcerative colitis and unintended interactions with cytochrome P450-dependent drug-metabolizing enzymes
Şen, Alaattin (TUBİTAK, 2022)Ulcerative colitis (UC) is an idiopathic, chronic inflammatory disease with multiple genetic and a variety of environmental risk factors. Although current drugs significantly aid in controlling the disease, many people ... -
Prophylactic and therapeutic roles of oleanolic acid and its derivatives in several diseases
Sen, Alaattin (BAISHIDENG PUBLISHING GROUP INC, 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES, 2020)Oleanolic acid (OA) and its derivatives are widely found in diverse plants and are naturally effective pentacyclic triterpenoid compounds with broad prophylactic and therapeutic roles in various diseases such as ulcerative ... -
Role of AHR, NF-kB and CYP1A1 crosstalk with the X protein of Hepatitis B virus in hepatocellular carcinoma cells
Celik-Turgut, Gurbet; Olmez, Nazmiye; Koc, Tugba; Ozgun-Acar, Ozden; Semiz, Asli; Dodurga, Yavuz; Satiroglu-Tufan, Naciye Lale; Sen, Alaattin (ELSEVIER, 2023)In this study, it was aimed to elucidate the interaction between aryl hydrocarbon receptor (AHR), nuclear factor -kappa B (NF-kB), and cytochrome P4501A1 (CYP1A1) with hepatitis B virus X protein (HBX) in a human liver ... -
Suppression of inflammatory cytokines expression with bitter melon (Momordica charantia) in TNBS-instigated ulcerative colitis
Acar, Ozden Ozgun; Cetin, Hulya; Semiz, Gurkan; Sen, Alaattin (SCIENDO, BOGUMILA ZUGA 32A, WARSAW, MAZOVIA, POLAND, 2020)Background and Objective: This study was aimed to elucidate the molecular mechanism of Momordica charantia (MCh), along with a standard drug prednisolone, in a rat model of colitis induced by trinitrobenzene sulfonic acid ... -
Synthesis and initial evaluation of efficacy of olean-12-en-28-ol, 3 beta-pentacosanoate for the symptomatic treatment of multiple sclerosis
Sen, A.; Senol, H.; Acar, O. Ozgun; Kale, E.; Dag, A.; Topcu, G. (WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2019)Synthesis and initial evaluation of efficacy of olean-12-en-28-ol, 3 beta-pentacosanoate for the symptomatic treatment of multiple sclerosis -
Synthesis of nitrogen-containing oleanolic acid derivatives as carbonic anhydrase and acetylcholinesterase inhibitors
Senol, Halil; Turgut, Gurbet Celik; Sen, Alaattin (SPRINGER BIRKHAUSER, 2023)In this study, a total of 13 compounds (5-17) were synthesized starting from oleanolic acid (OA), a natural triterpenoid. Five new compounds (10, 11, 12, 15 and 17), are the main targets of the study, which were synthesized ... -
Triterpenoids and steroids isolated from Anatolian Capparis ovata and their activity on the expression of inflammatory cytokines
Gazioglu, Isil; Semen, Sevcan; Acar, Ozden Ozgun; Kolak, Ufuk; Sen, Alaattin; Topcu, Gulacti (TAYLOR & FRANCIS LTD, 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND, 2020)Context CapparisL. (Capparaceae) is grown worldwide. Caper has been used in traditional medicine to treat various diseases including rheumatism, kidney, liver, stomach, as well as headache and toothache. Objective To isolate ...