Başlık için Yaşam ve Doğa Bilimleri Fakültesi listeleme
Toplam kayıt 151, listelenen: 80-99
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The Joubert syndrome protein CEP41 is excluded from the distal segment of cilia in C. elegans
(2021)Rare diseases are a fundamental issue in today's world, affecting more than 300 million individuals worldwide. According to data from Orphanet and OMIM, about 50-60 new conditions are added to the list of over 6,000 ... -
Liver fibrosis staging using CT image texture analysis and soft computing
(ELSEVIER, 2014)Liver biopsy is considered to be the gold standard for analyzing chronic hepatitis and fibrosis; however, it is an invasive and expensive approach, which is also difficult to standardize. Medical imaging techniques such ... -
Major apoptotic mechanisms and genes involved in apoptosis
(SAGE PUBLICATIONS LTD1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND, 2016)As much as the cellular viability is important for the living organisms, the elimination of unnecessary or damaged cells has the opposite necessity for the maintenance of homeostasis in tissues, organs and the whole organism. ... -
Matching variants for functional characterization of genetic variants
(Genetics Society of America, 2023)Rapid and low-cost sequencing, as well as computer analysis, have facilitated the diagnosis of many genetic diseases, resulting in a substantial rise in the number of disease-associated genes. However, genetic diagnosis ... -
A methodology to evaluate the sensory properties of instant hot chocolate beverage with different fat contents: multi-criteria decision-making techniques approach
(SPRINGERONE NEW YORK PLAZA, SUITE 4600 , NEW YORK, NY 10004, UNITED STATES, 2016)The multi-criteria decision-making techniques are applied in many areas such as integrated manufacturing systems, evaluation of technology investment, water and agriculture management and energy planning. However, there ... -
Microfluidic Devices: A New Paradigm in Toxicity Studies
(Hacettepe Üniversitesi, 2020)In recent years, great emphasis has been placed on non-animal toxicological methods (e.g. in vitro models, in silico or −omicsdata) as alternative strategies to reduce animal-testing, in line with the 3R (Replacement, ... -
MicroRNA prediction based on 3D graphical representation of RNA secondary structures
(TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, ATATURK BULVARI NO 221, KAVAKLIDERE, ANKARA, 00000, TURKEY, 2019)MicroRNAs (miRNAs) are posttranscriptional regulators of gene expression. While a miRNA can target hundreds of messenger RNA (mRNAs), an mRNA can be targeted by different miRNAs, not to mention that a single miRNA might ... -
A minimally invasive transfer method of mesenchymal stem cells to the intact periodontal ligament of rat teeth: a preliminary study
(TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, ATATURK BULVARI NO 221, KAVAKLIDERE, ANKARA, 00000, TURKEY, 2018)The aim of this study was to introduce a minimally invasive procedure for mesenchymal stem cell (MSC) transfer into the intact periodontal ligament (PDL) of the molar teeth in rats. Ten 12-week-old Wistar albino rats were ... -
miRcorrNetPro: Unraveling Algorithmic Insights through Cross-Validation in Multi-Omics Integration for Comprehensive Data Analysis
(Institute of Electrical and Electronics Engineers Inc., 2023)High throughput -omics technologies facilitate the investigation of regulatory mechanisms of complex diseases. Along this line, scientists develop promising tools and methods to extend our understanding at the molecular ... -
A molecular and biophysical comparison of macromolecular changes in imatinib-sensitive and imatinib-resistant K562 cells exposed to ponatinib
(SAGE PUBLICATIONS LTD, 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND, 2016)Chronic myeloid leukemia (CML) is a type of hematological malignancy that is characterized by the generation of Philadelphia chromosome encoding BCR/ABL oncoprotein. Tyrosine kinase inhibitors (TKIs), imatinib, nilotinib, ... -
Molecular mechanisms of drug resistance and its reversal in cancer
(Taylor and Francis, 2016)Chemotherapy is the main strategy for the treatment of cancer. However, the main problem limiting the success of chemotherapy is the development of multidrug resistance. The resistance can be intrinsic or acquired. The ... -
Natural diterpenoid alysine A isolated from Teucrium alyssifolium exerts antidiabetic effect via enhanced glucose uptake and suppressed glucose absorption
(SCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY-TUBITAK, ATATURK BULVARI NO 221, KAVAKLIDERE, TR-06100 ANKARA, TURKEY, 2019)Teucrium species have been used in folk medicine as antidiabetic, antiinflammatory, antiulcer, and antibacterial agents. We have explored in vitro antidiabetic impacts of 2 natural diterpenoids, alysine A and alysine B, ... -
NeRNA: A negative data generation framework for machine learning applications of noncoding RNAs
(PERGAMON-ELSEVIER SCIENCE, 2023)Many supervised machine learning based noncoding RNA (ncRNA) analysis methods have been developed to classify and identify novel sequences. During such analysis, the positive learning datasets usually consist of known ... -
A Novel Natural Product, KL-21, Inhibits Proliferation and Induces Apoptosis in Chronic Lymphocytic Leukemia Cells
(GALENOS YAYINCILIK, ERKAN MOR, MOLLA GURANI CAD 21-1, FINDIKZADE, ISTANBUL 34093, TURKEY, 2015)Objective: The aims of this study were to examine the cytotoxic and apoptotic effects of KL-21, a novel plant product (produced by Naturin Natural Products, Izmir, Turkey), on 232B4 chronic lymphocytic leukemia (CLL) cells ... -
A novel signaling pathway that governs tumor metastasis: ceramide regulates direct crosstalk between TGF-beta and sonic hedgehog signaling
(WILEY111 RIVER ST, HOBOKEN 07030-5774, NJ, 2016)A novel signaling pathway that governs tumor metastasis: ceramide regulates direct crosstalk between TGF-beta and sonic hedgehog signaling -
A Novel Signaling Pathway that Governs Tumor Metastasis: Ceramide Regulates Direct Crosstalk Between TGF-beta and Sonic Hedgehog Signaling
(WILEY111 RIVER ST, HOBOKEN 07030-5774, NJ, 2016)A Novel Signaling Pathway that Governs Tumor Metastasis: Ceramide Regulates Direct Crosstalk Between TGF-beta and Sonic Hedgehog Signaling -
Obesity induced by high-fat diet is associated with critical changes in biological and molecular functions of mesenchymal stromal cells present in visceral adipose tissue
(Impact Journals LLC, 2020)The mesenchymal stromal cells (MSCs) residing within the stromal component of visceral adipose tissue appear to be greatly affected by obesity, with impairment of their functions and presence of senescence. To gain further ... -
On the detailed mechanical response investigation of PHBV/PCL and PHBV/PLGA electrospun mats
(IOP PUBLISHING LTD, TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND, 2019)In this study, electrospun mats of pristine poly(epsilon-caprolactone) (PCL), Poly(D, L-lactide-co-glycolide) (PLGA), poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), as well as PHBV/PCL blends and PHBV/PLGA blends in ... -
Orally administered docetaxel-loaded chitosan-decorated cationic PLGA nanoparticles for intestinal tumors: formulation, comprehensive in vitro characterization, and release kinetics
(BEILSTEIN-INSTITUT, 2022)Intestinal cancers are the third most lethal cancers globally, beginning as polyps in the intestine and spreading with a severe meta-static tendency. Chemotherapeutic drugs used in the treatment of intestinal tumors are ... -
PACLITAXEL-LOADED POLYCAPROLACTONE NANOPARTICLES FOR LUNG TUMORS; FORMULATION, COMPREHENSIVE IN VITRO CHARACTERIZATION AND RELEASE KINETIC STUDIES
(Ankara Üniversitesi, 2022)Objective: Today, cancer is still among the most common chronic diseases. Nanoparticular drug delivery systems prepared with biocompatible and biodegradable polymers such as polycaprolactone are rational solution for ...
