Yazar "AGÜ, Yaşam ve Doğa Bilimleri Fakültesi, Moleküler Biyoloji ve Genetik Bölümü" için Yaşam ve Doğa Bilimleri Fakültesi listeleme
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Akut Myeloid Lösemi Tedavisi için Hedgehog Ve Otofaji Yolaklarının Düzenlenmesi
EL KHATIB, Mona (TUBİTAK, 2019)Akut myeloid lösemi (AML) çeşitli moleküler aberasyonlar ve sinyal yolaklarındaki bozuklukları içeren klonal hastalıklar ile karakterize edilen bir grup heterojen malignanttır. Hedgehog (HH) sinyal yolağı birçok kanserde ... -
An answer to colon cancer treatment by mesenchymal stem cell originated from adipose tissue
Iplik, Elif; Ertugrul, Baris; Kozanoglu, İlknur; Baran, Yusuf; Cakmakoglu, Bedia (MASHHAD UNIV MED SCIENCES, VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 - 445, MASHHAD, 00000, IRAN, 2018)Objective(s): Colon cancer is risen up with its complex mechanism that directly impacts on its treatment as well as its common prevalence. Mesenchymal stem cells (MSCs) have been considered as a therapeutic candidate for ... -
Apatinib Sensitizes Human Breast Cancer Cells against Navitoclax and Venetoclax Despite Up-regulated Bcl-2 and Mcl-1 Gene Expressions
Kavakcioglu Yardimci, Berna; Ozgun Acar, Ozden; Semiz, Asli; Sen, Alaattin (KARE PUBLCONCORD ISTANBUL, DUMLUPINAR MAH, CIHAN SK NO 15, B BLOK 162 KADIKOY, ISTANBUL, TURKEY, 2021)OBJECTIVE Defects in apoptotic cell death which restrict the success of conventional cytotoxic therapies have pivotal roles in a number of pathological conditions including cancer. However, a novel drug class targeting ... -
Apoptotic effects of non-edible parts of Punica granatum on human multiple myeloma cells
Kiraz, Yagmur; Neergheen-Bhujun, Vidushi S.; Rummun, Nawraj; Baran, Yusuf (SAGE PUBLICATIONS LTD, 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND, 2016)Multiple myeloma is of great concern since existing therapies are unable to cure this clinical condition. Alternative therapeutic approaches are mandatory, and the use of plant extracts is considered interesting. Punica ... -
Biochemical, pharmacological, and toxicological attributes of caper (Capparis ovata) flowering buds and berries pickles
Ozgun-Acar, Ozden; Celik-Turgut, Gurbet; Guner, Huseyin; Sezer, Serdar; Sen, Alaattin (WILEY, 2022)Capparis ovata is a natural plant that grows widely in Turkey and its flowering buds and berry pickle are used in traditional medicine. Thus, the current study was expanded to evaluate the biochemical, pharmacological, ... -
Cell Proliferation and Cytotoxicity Assays
Adan, Aysun; Kiraz, Yagmur; Baran, Yusuf (BENTHAM SCIENCE PUBL LTDEXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES, 2016)Cell viability is defined as the number of healthy cells in a sample and proliferation of cells is a vital indicator for understanding the mechanisms in action of certain genes, proteins and pathways involved cell survival ... -
Ceramide is A Key Factor That Regulates The Crosstalk Between TGF-beta and Sonic Hedgehog Signaling at The Basal Cilia To Control Cell Migration and Tumor Metastasis
Gencer, Salih; Oleinik, Natalia; Dany, Mohammed; Ogretmen, Besim (WILEY111 RIVER ST, HOBOKEN 07030-5774, NJ, 2016)Ceramide is A Key Factor That Regulates The Crosstalk Between TGF-beta and Sonic Hedgehog Signaling at The Basal Cilia To Control Cell Migration and Tumor Metastasis -
Ceramide is a key factor that regulates the crosstalk between TGF-beta and sonic hedgehog signaling at the basal cilia to control cell migration and tumor metastasis
Gencer, Salih; Ogretmen, Besim (ELSEVIER SCI LTDTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND, 2016)Ceramide is a key factor that regulates the crosstalk between TGF-beta and sonic hedgehog signaling at the basal cilia to control cell migration and tumor metastasis -
Cerium Oxide Nanoparticles Biosynthesized Using Fresh Green Walnut Shell in Microwave Environment and their Anticancer Effect on Breast Cancer Cells
Sulak, Mine; Turgut, Gurbet Celik; Sen, Alaattin (John Wiley and Sons Inc, 2022)In this study, cerium oxide nanoparticles (CONPs) were synthesized using fresh green walnut shell extract in microwave environment. The morphology and structure of the CONPs were determined using ultraviolet-visible (UV/VIS), ... -
Combined effect of midostaurin and sphingosine kinase-1 inhibitor on FMS-like tyrosine kinase 3 (FLT3) wild type acute myeloid leukemia cells
Adan, Aysun; Şahin, Hande Nur (De Gruyter, 2022)Objectives Therapeutic potential of clinically approved FLT3 inhibitor midostaurin has been neglected in wild-type FLT3 positive acute myeloid leukemia (AML). Sphingosine kinase-1 (SK-1) having anti-proliferative functions ... -
Common miRNA signatures in a group of rare neuromuscular disorders
Aksu, E; Akkaya-Ulum, Y. Z; Balci-Peynircioglu, B.; Dayangac-Erden, D.; Yuzbasioglu, A.; Bakir-Gungor, B.; Talim, B.; Balci-Hayta, B. (WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018)Common miRNA signatures in a group of rare neuromuscular disorders -
A comparative study on normal and obese mice indicates that the secretome of mesenchymal stromal cells is influenced by tissue environment and physiopathological conditions
Ayaz-Guner, Serife; Alessio, Nicola; Acar, Mustafa B.; Aprile, Domenico; Ozcan, Servet; Di Bernardo, Giovanni; Peluso, Gianfranco; Galderisi, Umberto (BMC, CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND, 2020)Background: The term mesenchymal stromal cells (MSCs) designates an assorted cell population comprised of stem cells, progenitor cells, fibroblasts, and stromal cells. MSCs contribute to the homeostatic maintenance of many ... -
Complementary medicines used in ulcerative colitis and unintended interactions with cytochrome P450-dependent drug-metabolizing enzymes
Şen, Alaattin (TUBİTAK, 2022)Ulcerative colitis (UC) is an idiopathic, chronic inflammatory disease with multiple genetic and a variety of environmental risk factors. Although current drugs significantly aid in controlling the disease, many people ... -
Computational analysis of microRNA-mediated interactions in SARS-CoV-2 infection
Demirci, Muserref Duygu Sacar; Adan, Aysun (PEERJ INC, 341-345 OLD ST, THIRD FLR, LONDON, EC1V 9LL, ENGLAND, 2020)MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression found in more than 200 diverse organisms. Although it is still not fully established if RNA viruses could generate miRNAs, there are examples of ... -
COMPUTATIONAL IDENTIFICATION OF MICRORNAS FROM SSDNA VIRUSES
Saçar Demirci, Müşerref Duygu (Eskişehir Teknik Üniversitesi, 2018)MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression and the fact that they are associated with various disease phenotypes is one of the main reasons for their importance. The complexity of experimental ... -
Conserved clinical variation visualization tool (ConVarT)
Kaplan, O. I.; Torun, F. M.; Guner, H.; Cevik, S. (NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND, 2019)Conserved clinical variation visualization tool (ConVarT) -
Cytotoxic and Cytostatic Effects of Targeting mTOR and Hedgehog Pathways in Acute Myeloid Leukemia
Çiçek, Enes; Kucuktas, Fulya Mina; Yenigul, Munevver; Gencer Akcok, Emel Basak (İstanbul Üniversitesi Yayınevi, 2022)Objectives: Acute myeloid leukemia (AML) is a highly aggressive heterogeneous hematopoietic malignancy characterized by a rapid and abnormal proliferation of immature myeloid leukemia cells in the bone marrow and peripheral ... -
Cytotoxic Effects of Resveratrol and Its Combinations with Ceramide Metabolism Inhibitors on FLT3 Positive Acute Myeloid Leukemia
ERSÖZ, Nur Şebnem; ADAN, Aysun (DergiPark, 2020)Sphingolipids determine the cell fate by regulating cell proliferation and growth. Ceramide, growth inhibitory lipid, might be produced through de novo pathway or salvage pathway, which is converted to proliferation inducers ... -
Differential in vitro anti-leukemic activity of resveratrol combined with serine palmitoyltransferase inhibitor myriocin in FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) carrying AML cells
Ersoz, Nur Sebnem; Adan, Aysun (SPRINGER, 2022)Treatment of FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) AML is restricted due to toxicity, drug resistance and relapse eventhough targeted therapies are clinically available. Resveratrol with its ... -
Dual Targeting of DNA Damage Response Proteins Implicated in Cancer Radioresistance
Vasilopoulos, Spyridon N.; Güner, Hüseyin; Uça Apaydın, Merve; Pavlopoulou, , Athanasia; Georgakilas, Alexandros G. (Multidisciplinary Digital Publishing Institute (MDPI), 2023)Ionizing radiation can induce different types of DNA lesions, leading to genomic instability and ultimately cell death. Radiation therapy or radiotherapy, a major modality in cancer treatment, harnesses the genotoxic ...