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Inflammatory bowel disease biomarkers of human gut microbiota selected via different feature selection methods
(PEERJ INC, 2022)
The tremendous boost in next generation sequencing and in the “omics” technologies makes it possible to characterize the human gut microbiome—the collective genomes of the microbial community that reside in our gastrointestinal ...
AMP-GSM: Prediction of Antimicrobial Peptides via a Grouping–Scoring–Modeling Approach
(MDPI, 2023)
Due to the increasing resistance of bacteria to antibiotics, scientists began seeking new solutions against this problem. One of the most promising solutions in this field are antimicrobial peptides (AMP). To identify ...
PriPath: identifying dysregulated pathways from differential gene expression via grouping, scoring, and modeling with an embedded feature selection approach
(BMC, 2023)
BackgroundCell homeostasis relies on the concerted actions of genes, and dysregulated genes can lead to diseases. In living organisms, genes or their products do not act alone but within networks. Subsets of these networks ...
Invention of 3Mint for feature grouping and scoring in multi-omics
(FRONTIERS MEDIA SA, 2023)
Advanced genomic and molecular profiling technologies accelerated the enlightenment of the regulatory mechanisms behind cancer development and progression, and the targeted therapies in patients. Along this line, intense ...
TextNetTopics Pro, a topic model-based text classification for short text by integration of semantic and document-topic distribution information
(FRONTIERS MEDIA SA, 2023)
With the exponential growth in the daily publication of scientific articles, automatic
classification and categorization can assist in assigning articles to a predefined
category. Article titles are concise descriptions ...
GeNetOntology: identifying affected gene ontology terms via grouping, scoring, and modeling of gene expression data utilizing biological knowledge-based machine learning
(FRONTIERS MEDIA SA, 2023)
Introduction: Identifying significant sets of genes that are up/downregulated under specific conditions is vital to understand disease development mechanisms at the molecular level. Along this line, in order to analyze ...
miRModuleNet: Detecting miRNA-mRNA Regulatory Modules
(RONTIERS MEDIA SAAVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE CH-1015, SWITZERLAND, 2022)
Increasing evidence that microRNAs (miRNAs) play a key role in carcinogenesis has revealed the need for elucidating the mechanisms of miRNA regulation and the roles of miRNAs in gene-regulatory networks. A better understanding ...
Prediction of Linear Cationic Antimicrobial Peptides Active against Gram-Negative and Gram-Positive Bacteria Based on Machine Learning Models
(MDPI, 2022)
Antimicrobial peptides (AMPs) are considered as promising alternatives to conventional antibiotics in order to overcome the growing problems of antibiotic resistance. Computational prediction approaches receive an increasing ...
miRdisNET: Discovering microRNA biomarkers that are associated with diseases utilizing biological knowledge-based machine learning
(Frontiers Media S.A., 2023)
During recent years, biological experiments and increasing evidence have shown that microRNAs play an important role in the diagnosis and treatment of human complex diseases. Therefore, to diagnose and treat human complex ...
A toolbox of machine learning software to support microbiome analysis
(Frontiers Media SA, 2023)
The human microbiome has become an area of intense research due to its
potential impact on human health. However, the analysis and interpretation
of this data have proven to be challenging due to its complexity and ...