Yazar "AGÜ, Yaşam ve Doğa Bilimleri Fakültesi, Moleküler Biyoloji ve Genetik Bölümü" için WoS İndeksli Yayınlar Koleksiyonu listeleme
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Major apoptotic mechanisms and genes involved in apoptosis
Kiraz, Yagmur; Adan, Aysun; Yandim, Melis Kartal; Baran, Yusuf (SAGE PUBLICATIONS LTD1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND, 2016)As much as the cellular viability is important for the living organisms, the elimination of unnecessary or damaged cells has the opposite necessity for the maintenance of homeostasis in tissues, organs and the whole organism. ... -
Matching variants for functional characterization of genetic variants
Cevik-Kaplan, Sebiha; Zhao, Pei; Zorluer, Atiyye; Pir, Mustafa Samet; Bian, Wenyin (Genetics Society of America, 2023)Rapid and low-cost sequencing, as well as computer analysis, have facilitated the diagnosis of many genetic diseases, resulting in a substantial rise in the number of disease-associated genes. However, genetic diagnosis ... -
A minimally invasive transfer method of mesenchymal stem cells to the intact periodontal ligament of rat teeth: a preliminary study
Amuk, Nisa Gul; Kurt, Gökmen; Kartal Yandım, Melis; Adan, Aysun; Baran, Yusuf (TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, ATATURK BULVARI NO 221, KAVAKLIDERE, ANKARA, 00000, TURKEY, 2018)The aim of this study was to introduce a minimally invasive procedure for mesenchymal stem cell (MSC) transfer into the intact periodontal ligament (PDL) of the molar teeth in rats. Ten 12-week-old Wistar albino rats were ... -
A molecular and biophysical comparison of macromolecular changes in imatinib-sensitive and imatinib-resistant K562 cells exposed to ponatinib
Yandim, Melis Kartal; Ceylan, Cagatay; Elmas, Efe; Baran, Yusuf (SAGE PUBLICATIONS LTD, 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND, 2016)Chronic myeloid leukemia (CML) is a type of hematological malignancy that is characterized by the generation of Philadelphia chromosome encoding BCR/ABL oncoprotein. Tyrosine kinase inhibitors (TKIs), imatinib, nilotinib, ... -
Natural diterpenoid alysine A isolated from Teucrium alyssifolium exerts antidiabetic effect via enhanced glucose uptake and suppressed glucose absorption
Sen, Alaattin; Ayar, Buket; Yilmaz, Anil; Acar, Ozden Ozgun; Turgut, Gurbet Celik; Topcu, Gulacti (SCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY-TUBITAK, ATATURK BULVARI NO 221, KAVAKLIDERE, TR-06100 ANKARA, TURKEY, 2019)Teucrium species have been used in folk medicine as antidiabetic, antiinflammatory, antiulcer, and antibacterial agents. We have explored in vitro antidiabetic impacts of 2 natural diterpenoids, alysine A and alysine B, ... -
A Novel Natural Product, KL-21, Inhibits Proliferation and Induces Apoptosis in Chronic Lymphocytic Leukemia Cells
Gokbulut, Aysun Adan; Yasar, Mustafa; Baran, Yusuf (GALENOS YAYINCILIK, ERKAN MOR, MOLLA GURANI CAD 21-1, FINDIKZADE, ISTANBUL 34093, TURKEY, 2015)Objective: The aims of this study were to examine the cytotoxic and apoptotic effects of KL-21, a novel plant product (produced by Naturin Natural Products, Izmir, Turkey), on 232B4 chronic lymphocytic leukemia (CLL) cells ... -
Obesity induced by high-fat diet is associated with critical changes in biological and molecular functions of mesenchymal stromal cells present in visceral adipose tissue
Acar M.B.; Ayaz-Guner S.; Bernardo G.D.; Guner H.; Murat A.; Peluso G.; Ozcan S.; Galderisi U. (Impact Journals LLC, 2020)The mesenchymal stromal cells (MSCs) residing within the stromal component of visceral adipose tissue appear to be greatly affected by obesity, with impairment of their functions and presence of senescence. To gain further ... -
The pleiotropic effects of fisetin and hesperetin on human acute promyelocytic leukemia cells are mediated through apoptosis, cell cycle arrest, and alterations in signaling networks
Adan, Aysun; Baran, Yusuf (SAGE PUBLICATIONS LTD1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND, 2016)Fisetin and hesperetin, flavonoids from various plants, have several pharmaceutical activities including antioxidative, anti-inflammatory, and anticancer effects. However, studies elucidating the role and the mechanism(s) ... -
Precision medicine in oncology: Challenges, stakes and new paradigms
Cox, Stephanie; Rousseau-Tsangaris, Marina; Abou-Zeid, Nancy; Dalle, Stephane; Leurent, Pierre; Cutivet, Arnaud; Le, Hai-Ha; Kotb, Shady; Bogaert, Brenda; Gardette, Robert; Baran, Yusuf; Holder, Jean-Marc; Lerner, Larisa; Blay, Jean-Yves; Cambrosio, Alberto; Tredan, Olivier; Denefle, Patrice (JOHN LIBBEY EUROTEXT LTD, 127 AVE DE LA REPUBLIQUE, 92120 MONTROUGE, FRANCE, 2019)Precision medicine in oncology: Challenges, stakes and new paradigms -
Predicting potential of pressure retarded osmosis power for different estuaries in Turkey
Saki, Seda; Uzal, Nigmet; Gokcek, Murat; Ates, Nuray (WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2019)Pressure retarded osmosis (PRO) is an alternative renewable energy source recovered from the salinity gradient between the fresh water (feed solution) and salty water (draw solution). In order to implement osmotic power, ... -
Progression of irradiated mesenchymal stromal cells from early to late senescence: Changes in SASP composition and anti-tumour properties
Alessio, Nicola; Acar, Mustafa Burak; Squillaro, Tiziana; Aprile, Domenico; Ayaz-Güner, Şerife; Di Bernardo, Giovanni; Peluso, Gianfranco; Özcan, Servet; Galderisi, Umberto (WILEY Online Library, 2023)Genotoxic injuries converge on senescence-executive program that promotes production of a senescence-specific secretome (SASP). The study of SASP is particularly intriguing, since through it a senescence process, triggered ... -
Prophylactic and therapeutic roles of oleanolic acid and its derivatives in several diseases
Sen, Alaattin (BAISHIDENG PUBLISHING GROUP INC, 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES, 2020)Oleanolic acid (OA) and its derivatives are widely found in diverse plants and are naturally effective pentacyclic triterpenoid compounds with broad prophylactic and therapeutic roles in various diseases such as ulcerative ... -
Proteomic and Biological Analysis of the Effects of Metformin Senomorphics on the Mesenchymal Stromal Cells
Acar, Mustafa Burak; Ayaz-Guner, Serife; Gunaydin, Zeynep; Karakukcu, Musa; Peluso, Gianfranco; Di Bernardo, Giovanni; Ozcan, Servet; Galderisi, Umberto (FRONTIERS MEDIA SAAVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE CH-1015, SWITZERLAND, 2021)Senotherapeutics are new drugs that can modulate senescence phenomena within tissues and reduce the onset of age-related pathologies. Senotherapeutics are divided into senolytics and senomorphics. The senolytics selectively ... -
Protocol for cell surface biotinylation of magnetic labeled and captured human peripheral blood mononuclear cells
Ayaz-Guner, Serife; Acar, Mustafa Burak; Boyvat, Dudu; Guner, Huseyin; Bozalan, Habibe; Güzel, Melis; Yıldır, Selin Kübra; Altınsoy, Nilay; Fındık, Fatma; Karakükçü, Musa; Özcan, Servet (Cell Press, 2022)Analysis of the surfaceome of a blood cell subset requires cell sorting, followed by surface protein enrichment. Here, we present a protocol combining magnetically activated cell sorting (MACS) and surface biotinylation ... -
Revealing genome-wide mRNA and microRNA expression patterns in leukemic cells highlighted “hsa-miR-2278” as a tumor suppressor for regain of chemotherapeutic imatinib response due to targeting STAT5A
Kaymaz, Burçin Tezcanlı; Günel, Nur Selvi; Ceyhan, Metin; Çetintaş, Vildan Bozok; Özel, Buket; Yandım, Melis Kartal; Kıpçak, Sezgi; Aktan, Çağdaş; Gökbulut, Aysun Adan; Baran, Yusuf; Can, Buket Kosova (Kluwer Academic Publishers, 2015)BCR-ABL oncoprotein stimulates cell proliferation and inhibits apoptosis in chronic myeloid leukemia (CML). For cure, imatinib is a widely used tyrosine kinase inhibitor, but developing chemotherapeutic resistance has to ... -
Role of AHR, NF-kB and CYP1A1 crosstalk with the X protein of Hepatitis B virus in hepatocellular carcinoma cells
Celik-Turgut, Gurbet; Olmez, Nazmiye; Koc, Tugba; Ozgun-Acar, Ozden; Semiz, Asli; Dodurga, Yavuz; Satiroglu-Tufan, Naciye Lale; Sen, Alaattin (ELSEVIER, 2023)In this study, it was aimed to elucidate the interaction between aryl hydrocarbon receptor (AHR), nuclear factor -kappa B (NF-kB), and cytochrome P4501A1 (CYP1A1) with hepatitis B virus X protein (HBX) in a human liver ... -
Role of cytochrome P450 polymorphisms and functions in development of ulcerative colitis
Sen, Alaattin; Stark, Holger (BAISHIDENG PUBLISHING GROUP INC, 8226 REGENCY DR, PLEASANTON, CA 94588 USA, 2019)Cytochromes P450s (CYPs) are terminal enzymes in CYP dependent monooxygenases, which constitute a superfamily of enzymes catalysing the metabolism of both endogenous and exogenous substances. One of their main tasks is to ... -
Sex effect on the correlation of immunoglobulin G glycosylation with rheumatoid arthritis disease activity
Ercan, Altan (TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, ATATURK BULVARI NO 221, KAVAKLIDERE, ANKARA, 00000, TURKEY, 2020)Rheumatoid arthritis (RA) is a chronic autoimmune disease which affects females more than males with a presence of autoantibodies. Immunoglobulin G (IgG) produced by adaptive arm has 2 functional domains, Fc and Fab. The ... -
A subtractive proteomics approach for the identification of immunodominant Acinetobacter baumannii vaccine candidate proteins
Acar, Mustafa Burak; Ayaz-Guner, Serife; Guner, Huseyin; Dinc, Gokcen; Kilic, Aysegul Ulu; Doganay, Mehmet; Ozcan, Servet (FRONTIERS MEDIA SA, 2022)Background: Acinetobacter baumannii is one of the most life-threatening multidrug-resistant pathogens worldwide. Currently, 50%–70% of clinical isolates of A. baumannii are extensively drug-resistant, and available antibiotic ... -
Suppression of inflammatory cytokines expression with bitter melon (Momordica charantia) in TNBS-instigated ulcerative colitis
Acar, Ozden Ozgun; Cetin, Hulya; Semiz, Gurkan; Sen, Alaattin (SCIENDO, BOGUMILA ZUGA 32A, WARSAW, MAZOVIA, POLAND, 2020)Background and Objective: This study was aimed to elucidate the molecular mechanism of Momordica charantia (MCh), along with a standard drug prednisolone, in a rat model of colitis induced by trinitrobenzene sulfonic acid ...