Yazar "AGÜ, Yaşam ve Doğa Bilimleri Fakültesi, Biyomühendislik Bölümü" için WoS İndeksli Yayınlar Koleksiyonu listeleme
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Orally administered docetaxel-loaded chitosan-decorated cationic PLGA nanoparticles for intestinal tumors: formulation, comprehensive in vitro characterization, and release kinetics
Unal, Sedat; Dogan, Osman; Aktas, Yesim (BEILSTEIN-INSTITUT, 2022)Intestinal cancers are the third most lethal cancers globally, beginning as polyps in the intestine and spreading with a severe meta-static tendency. Chemotherapeutic drugs used in the treatment of intestinal tumors are ... -
Poly(OEGMA)-b-Poly(4-VP) block copolymer nanocarriers for anticancer agent release
Aksit, N. N.; Topuzogullari, M.; Isoglu, I. A.; El Khatib, M.; Isoglu, S. Dincer (WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018)Today, the most common approach to treating cancer is to transport the active substances with nanocarriers, which is more advantageous than systemic administration. One of the major advantages of nanocarriers is that they ... -
Polyethylenimine Modified and Non-Modified Polymeric Micelles Used for Nasal Administration of Carvedilol
Kahraman, Emine; Karagoz, Ayse; Dinçer, Sevil; Ozsoy, Yildiz (AMER SCIENTIFIC PUBLISHERS, 2015)This study evaluates the ability of polyethylenimine-modified and non-modified polymeric micelles to enhance permeation through the nasal mucosa for a highly hydrophobic model drug. Carvedilol was loaded into polyethylen ... -
Preparation and Characterization of Viburnum Opulus Containing Electrospun Membranes as Antibacterial Wound Dressing
Yuruk, Adile; Isoglu, Sevil Dincer; Isoglu, Ismail Alper (KOREAN FIBER SOC, 2023)Herein, we fabricated polycaprolactone/gelatin electrospun membranes possessing different amounts of Viburnum Opulus extract (0, 25, 35, 50%, w/v) as an antibacterial wound dressing. We investigated chemical, morphological, ... -
Preparation of antibacterial electrospun poly(D, L-lactide-co-glycolide)/gelatin blend membranes containing Hypericum capitatum var. capitatum
Aksit, Nazende Nur; Gurdap, Seda; Isoglu, Sevil Dincer; Isoglu, Ismail Alper (TAYLOR & FRANCIS AS, KARL JOHANS GATE 5, NO-0154 OSLO, NORWAY, 2020)In this study, we fabricated poly(D, L-lactide-co-glycolide)/gelatin (PLGA/gelatin) membranes containing different amounts of Hypericum capitatum var. capitatum (HCC) extract (1, 5, 7.5, 10 wt%) by electrospinning technique. ... -
RAFT-mediated synthesis of poly(N-(2-hydroxypropyl)methacrylamide-b-4-vinylpyridine) by conventional and microwave heating
Ozdemir, Zeynep; Topuzogullari, Murat; İsoglu, Ismail Alper; Dincer, Sevil (SPRINGERONE NEW YORK PLAZA, SUITE 4600 , NEW YORK, NY 10004, UNITED STATES, 2013)We report the synthesis of N-(2-hydroxypropyl)methacrylamide (HPMA) macroCTA and HPMA-b-4-Vinylpyridine block copolymers via reversible addition-fragmentation chain transfer (RAFT) reaction. Polymerization was carried out ... -
Relationship Between Neutrophil Gelatinase-associated Lipocalin and Mortality in Acute Kidney Injury
Aksebzeci, Bekir Hakan; Kayaaltı, Seda; Kayaaltı, Ömer (GALENOS YAYINCILIK, ERKAN MOR, MOLLA GURANI CAD 21-1, FINDIKZADE, ISTANBUL 34093, TURKEY, 2018)Objective: Almost half of intensive care patients are affected by acute kidney injury (AKI). The purpose of this study is to determine parameters that can be used for predicting of early (within 28 days) and late (within ... -
Resveratrol triggers anti-proliferative and apoptotic effects in FLT3-ITD-positive acute myeloid leukemia cells via inhibiting ceramide catabolism enzymes
Ersoz, Nur Sebnem; Adan, Aysun (HUMANA PRESS INC, 2022)Resveratrol possesses well-defned anti-carcinogenic activities. However, how resveratrol exerts its anti-leukemic actions by modulating anti-apoptotic ceramide catabolism enzymes, mainly sphingosine kinase (SK-1) and ... -
RPI-1 (human DCDC2) displays functional redundancy with Nephronophthisis 4 in regulating cilia biogenesis in C. elegans
Kaplan, Oktay İsmail (TUBİTAK, 2023)Projecting from most cell surfaces, cilia serve as important hubs for sensory and signaling processes and have been linked to a variety of human disorders, including Bardet-Biedl Syndrome (BBS), Meckel-Gruber Syndrome ... -
Stem cells combined 3D electrospun nanofibrous and macrochannelled matrices: a preliminary approach in repair of rat cranial bones
İşoğlu, İsmail Alper; Bölgen, Nimet; Korkusuz, Petek; Vargel, İbrahim; Çelik, Hakan Hamdi; Kılıç, Emine; Güzel, Elif; Çavuşoğlu, Tarık; Uçkan, Duygu; Pişkin, Erhan (Taylor & Francis Group, 2019)Repair of cranial bone defects is an important problem in the clinical area. The use of scaffolds combined with stem cells has become a focus in the reconstruction of critical-sized bone defects. Electrospinning became a ... -
Sulfobetaine-Based Homo- and Copolymers by RAFT: Cross-Linked Micelles and Aqueous Solution Properties
Gurdap, Seda; Bayram, Nazende Nur; Isoglu, Ismail Alper; Isoglu Dincer, Sevil (AMER CHEMICAL SOC, 2022)In this study, we describe the synthesis and aqueous solution behavior of temperature-sensitive N-(3-sulfopropyl)-N-methacroyloxyethyl-N,N-dimethylammonium betaine (SBMA) homopolymers and core cross-linked micelles (CCMs) ... -
TACTILE SENSITIVITY and CAPABILITY OF SOFT-SOLID TEXTURE DISCRIMINATION
Aktar, Tugba; Ettelaie, Rammile; Chen, Jianshe; Holmes, Melvin (WILEY, 2015)The sensation and perception of food texture is regulated by tactile-dominated mechanisms and therefore, it is believed that one’s capability in discriminating food textural properties could be related to one’s tactile ... -
Thermo-Responsive Complexes of c-Myc Antisense Oligonucleotide with Block Copolymer of Poly(OEGMA) and Quaternized Poly(4-Vinylpyridine)
Topuzogullari, Murat; Elalmis, Yeliz Basaran; Isoglu, Sevil Dincer (WILEY-V C H VERLAG GMBHPOSTFACH 101161, 69451 WEINHEIM, GERMANY, 2017)Solution behavior of thermo-responsive polymers and their complexes with biological macromolecules may be affected by environmental conditions, such as the concentration of macromolecular components, pH, ion concentration, ... -
Time-Dependent Reduction of Calcium Oscillations in Adipose-Derived Stem Cells Differentiating towards Adipogenic and Osteogenic Lineage
Torre, Enrico C.; Bicer, Mesude; Cottrell, Graeme S.; Widera, Darius; Tamagnini, Francesco (MDPIST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND, 2021)Adipose-derived mesenchymal stromal cells (ASCs) are multipotent stem cells which can differentiate into various cell types, including osteocytes and adipocytes. Due to their ease of harvesting, multipotency, and low ... -
A Top-Down Approach for Finding Affected Pathway Subnetworks in Type 2 Diabetes
Unlu Yazici, Miray; Bakir-Gungor, Burcu (IEEE, 2020)Diyabet (Diabetes Mellitus, DM), insülin üreten pankreas beta hücrelerindeki fonksiyon bozukluğu, insülin direnci veya insülinin işlevselliğinin bozulması ile meydana gelen bir tür metabolik bozukluktur. Diyabet vakalarının ... -
Uncovering Membrane-Bound Models of Coagulation Factors by Combined Experimental and Computational Approaches
Ohkubo, Y. Zenmei; Madsen, Jesper J. (GEORG THIEME VERLAG KGRUDIGERSTR 14, D-70469 STUTTGART, GERMANY, 2021)In the life sciences, including hemostasis and thrombosis, methods of structural biology have become indispensable tools for shedding light on underlying mechanisms that govern complex biological processes. Advancements ...