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dc.contributor.authorDogan, Refika Sultan
dc.contributor.authorSaka, Samed
dc.contributor.authorGungor, Burcu Bakir
dc.date.accessioned2021-06-18T11:41:44Z
dc.date.available2021-06-18T11:41:44Z
dc.date.issued2020en_US
dc.identifier.isbn978-1-7281-7565-2
dc.identifier.urihttps://hdl.handle.net/20.500.12573/823
dc.description.abstractHepatocellular carcinoma (HCC) is the most common cause of cancer-related death in the world. The molecular changes in the organism during the development of HCC are not fully understood. The aim of the present study is to contribute to the identification of critical genes and pathways associated with HCC via integrating various bioinformatics methods. In this study, experiments were conducted on gene expression data of 14 HCC tissues and non-cancerous control tissues. A total of 1229 genes, which show a statistically significant change between the groups, were identified. Among these, 681 genes were upregulated and 548 genes were downregulated. Via mapping the detected genes into protein protein interaction networks, active subnetwork search, subnetwork topological analysis and functional enrichment analyses were carried out. The interactions between the molecular pathways affected by HCC were also presented.en_US
dc.description.sponsorshipIEEE Turkey Sect; Istanbul Teknik Univ; Gazi Univ; Atilim Univ; Dicle Univ; Turkiye Bilisim Vakfi; Kocaeli Univen_US
dc.language.isoturen_US
dc.publisherIEEE, 345 E 47TH ST, NEW YORK, NY 10017 USAen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthepatocellular carcinomaen_US
dc.subjectmolecular pathwaysen_US
dc.subjectnetwork topological analysisen_US
dc.subjectactive subnetwork searchen_US
dc.subjectGene expressionen_US
dc.titleInvestigation of Hepatocellular Carcinoma Molecular Mechanisms via in Silico Analysesen_US
dc.typeconferenceObjecten_US
dc.contributor.departmentAGÜ, Mühendislik Fakültesi, Bilgisayar Mühendisliği Bölümüen_US
dc.identifier.startpage318en_US
dc.identifier.endpage322en_US
dc.relation.journal2020 5TH INTERNATIONAL CONFERENCE ON COMPUTER SCIENCE AND ENGINEERING (UBMK)en_US
dc.relation.publicationcategoryKonferans Öğesi - Ulusal - Kurum Öğretim Elemanıen_US


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