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dc.contributor.authorAdan, Aysun
dc.contributor.authorBaran, Yusuf
dc.date.accessioned2021-08-26T12:13:14Z
dc.date.available2021-08-26T12:13:14Z
dc.date.issued2016en_US
dc.identifier.issn1010-4283
dc.identifier.issn1423-0380
dc.identifier.otherPubMed ID26408178
dc.identifier.urihttps://doi.org/10.1007/s13277-015-4118-3
dc.identifier.urihttps://hdl.handle.net/20.500.12573/964
dc.description.abstractFisetin and hesperetin, naturally occurring flavonoids, have been reported as novel antioxidants with chemopreventive/chemotherapeutic potential against various types of cancer. However, their mechanism of action in CML is still unknown. This particular study aims to evaluate the therapeutic potentials of fisetin and hesperetin and their effects on cell proliferation, apoptosis, and cell cycle progression in human K562 CML cells. The results indicated that fisetin and hesperetin inhibited cell proliferation and triggered programmed cell death in these cells. The latter was confirmed by mitochondrial membrane depolarization and an increase in caspase-3 activation. In addition to that, we have detected S and G2/Mcell cycle arrests and G0/G1 arrest upon fisetin and hesperetin treatment, respectively. To identify the altered genes and genetic networks in response to fisetin and hesperetin, whole-genome microarray analysis was performed. The microarray gene profiling analysis revealed some important signaling pathways including JAK/STAT pathway, KIT receptor signaling, and growth hormone receptor signaling that were altered upon fisetin and hesperetin treatment. Moreover, microarray data suggested potential candidate genes for targeted CML therapy. Fisetin and hesperetin significantly modulated the expression of genes involved in cell proliferation and division, apoptosis, cell cycle regulation, and other significant cellular processes such as replication, transcription, and translation. In conclusion, our results suggest that fisetin and hesperetin as potential natural agents for CML therapy.en_US
dc.language.isoengen_US
dc.publisherSAGE PUBLICATIONS LTD1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLANDen_US
dc.relation.isversionof10.1007/s13277-015-4118-3en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGene profilingen_US
dc.subjectApoptosisen_US
dc.subjectChronic myeloid leukemiaen_US
dc.subjectHesperetinen_US
dc.subjectFisetinen_US
dc.titleFisetin and hesperetin induced apoptosis and cell cycle arrest in chronic myeloid leukemia cells accompanied by modulation of cellular signalingen_US
dc.typearticleen_US
dc.contributor.departmentAGÜ, Yaşam ve Doğa Bilimleri Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.contributor.institutionauthorBaran, Yusuf
dc.contributor.institutionauthorAdan, Aysun
dc.identifier.volumeVolume 7 Issue 5 Page 5781-5795en_US
dc.relation.journalTUMOR BIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası - Editör Denetimli Dergien_US


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