• Bovine serum albumin (BSA)-Loaded polyvinyl alcohol (PVA) / chitosan (CH) / hydroxyapatite (HA) electrospun nanofibers for bone tissue regeneration 

  Bozdag, Mehmet; Urek, Ferhat; Cesur, Sumeyye; Sahin, Ali; Gunduz, Oguzhan (ELSEVIER, 2025)

  The natural bone structure consists of three different nanocomposite layers; a porous polymer ceramic part, a lamellar, and a fiber-matrix composition gives the bone its unique physical and biological properties. During ...

• eTNT: Enhanced TextNetTopics with Filtered LDA Topics and Sequential Forward / Backward Topic Scoring Approaches 

  Voskergian, Daniel; Jayousi, Rashid; Bakir-Gungor, Burcu (SCIENCE & INFORMATION-SAI ORGANIZATION LTD, 2024)

  TextNetTopics is a novel text classification-based topic modelling approach that focuses on topic selection rather than individual word selection to train a machine learning algorithm. However, one key limitation of ...

• Determination of promising inhibitors for N-SH2 domain of SHP2 tyrosine phosphatase: an in silico study 

  Akcok, Emel Basak Gencer; Guner, Huseyin; Akcok, Ismail (SPRINGER NATURE LINK, 2024)

  There are many genes that produce proteins related to diseases and these proteins can be targeted with drugs as a potential therapeutic approach. Recent advancement in drug discovery techniques have created new opportunities ...

• Pi3k-Akt-Mtor Yolağı Ve Histon Deasetilaz Enzimlerinin Hedeflenmesinin Akut Myeloid Lösemi Hücreleri Üzerine Antitümör Etkisinin Incelenmesi 

  Gencer Akçok, Emel Başak; Şansaçar, Merve; Karaca, Münevver; Okur, Tuğba (TÜBİTAK, 2022)

  Akut Miyeloid Lösemi (AML), periferik kan, kemik iliği, dalak ve karaciğerde blast adı verilen olgunlaşmamış miyeloid hücrelerin birikmesiyle karakterize edilen ve sonunda hematopoietik maligniteye yol açan bir hastalıktır. ...

• Revolutionizing dermatology: harnessing mesenchymal stem/stromal cells and exosomes in 3D platform for skin regeneration 

  Bicer,Mesude (Springer Nature Link, 2024)

  Contemporary trends reveal an escalating interest in regenerative medicine-based interventions for addressing refractory skin defects. Conventional wound healing treatments, characterized by high costs and limited efficacy, ...

• Revolutionizing dermatology: harnessing mesenchymal stem/stromal cells and exosomes in 3D platform for skin regeneration 

  Bicer, Mesude (SPRINGER NATURE LINK, 2024)

  Contemporary trends reveal an escalating interest in regenerative medicine-based interventions for addressing refractory skin defects. Conventional wound healing treatments, characterized by high costs and limited efficacy, ...

• Highly Potent New Probiotic Strains from Traditional Turkish Fermented Foods 

  Yigit, Mehmet Burak; Cebeci, Aysun (SPRINGER NATURE LINK, 2025)

  Traditional Turkish fermented foods like boza, pickles, and tarhana are recognized for their nutritional and health benefits, yet the probiotic potential of lactic acid bacteria (LAB) strains isolated from them remains ...

• Rapamycin and Niacin combination induces apoptosis and cell cycle arrest through autophagy activation on acute myeloid leukemia cells 

  Subay, Lale Beril; Akcok, Emel Basak Gencer; Akcok, Ismail (SPRINGER NATURE LINK, 2025)

  BackgroundAcute myeloid leukemia (AML) is a heterogeneous hematological malignancy caused by disorders in stem cell differentiation and excessive proliferation resulting in clonal expansion of dysfunctional cells called ...

• Preparation of antibacterial electrospun poly(D, L-lactide-co-glycolide)/gelatin blend membranes containing Hypericum capitatum var. capitatum 

  Akşit, Nazende Nur; Gürdap, Seda; Dinçer İşoğlu, Sevil; İşoğlu, İsmail Alper (TAYLOR & FRANCIS AS, 2021)

  In this study, we fabricated poly(D, L-lactide-co-glycolide)/gelatin (PLGA/gelatin) membranes containing different amounts of Hypericum capitatum var. capitatum (HCC) extract (1, 5, 7.5, 10 wt%) by electrospinning technique. ...

• ARL13B regulates juxtaposed cilia-cilia elongation in BBSome dependent manner in Caenorhabditis elegans 

  Turan, Merve Gul; Kantarci, Hanife; Cevik, Sebiha; Kaplan, Oktay I. (CELL PRESS, 2025)

  The interaction of cilia with various cellular compartments, such as axons, has emerged as a new form of cellular communication. Cilia often extend in proximity to cilia from neighboring cells. However, the mechanisms ...

• Aurora Kinases: Their Role in Cancer and Cellular Processes 

  Sarı, Sibel; Özsoy, Elif Rumeysa (Bingöl Üniversitesi Fen Bilimleri Enstitüsü, 2024)

  Aurora kinases, belonging to a highly conserved family of serine/threonine kinases with critical roles in the regulation of the cell cycle, comprise three members: Aurora kinase A, B, and C, which serve as key mitotic ...

• Tomatidine, a Steroidal Alkaloid, Synergizes with Cisplatin to Inhibit Cell Viability and Induce Cell Death Selectively on FLT3-ITD+ Acute Myeloid Leukemia Cells 

  Ayvaz, Havva Berre; Yenigül, Münevver; Gencer Akçok, Emel Başak (SPRINGER NATURE Link, 2024)

  Background: Acute Myeloid Leukemia (AML) is a hematological cancer that frequently presents with a range of side effects and drug resistance during anticancer drug treatment. The current study aims to achieve increased ...

• A novel germline Pregnane X Receptor (PXR) variant predisposing to Hodgkin lymphoma in two siblings 

  Khodzhaev, Khusan; Sudutan, Tugce; Erbilgin, Yucel; Saritas, Merve; Yegen, Gulcin; Bozkurt, Ceyhun; Sayitoglu, Muge; Kebudi, Rejin (ELSEVIER, 2024)

  Hodgkin's lymphoma (HL) is the most common cancer in adolescents and young adults. A family history of HL increases the risk of developing HL in other family members. Identification of genetic predisposition variants in ...

• Emerging DNA Methylome Targets in FLT3-ITD-Positive Acute Myeloid Leukemia: Combination Therapy with Clinically Approved FLT3 Inhibitors 

  Tecik, Melisa; Adan, Aysun (SPRINGER LINK, 2024)

  The internal tandem duplication (ITD) mutation of the FMS-like receptor tyrosine kinase 3 (FLT3-ITD) is the most common mutation observed in approximately 30% of acute myeloid leukemia (AML) patients. It represents poor ...

• Draft genome of carotenoid-producing endophytic Pseudomonas sp. 102515 from Taxus chinensis 

  Fidan, Ozkan (American Society for Microbiology, 2024)

  Here, we report the draft genome sequence of endophytic Pseudomonas sp. 102515 isolated from Taxus chinensis collected from Logan, UT, USA. The genome is composed of 36 contigs and around 4.9 Mbp in size. The GC content ...

• Elucidating the complex membrane binding of a protein with multiple anchoring domains using extHMMM 

  Madsen, Jesper J.; Ohkubo, Y. Zenmei (Public Library of Science, 2024)

  Membrane binding is a crucial mechanism for many proteins, but understanding the specific interactions between proteins and membranes remains a challenging endeavor. Coagulation factor Va (FVa) is a large protein whose ...

• CilioGenics: an integrated method and database for predicting novel ciliary genes 

  Pir, Mustafa Samet; Begar, Efe; Yenisert, Ferhan; Demirci, Hasan C.; Korkmaz, Mustafa E.; Karaman, Asli; Tsiropoulou, Sofia; Firat-Karalar, Elif Nur; Blacque, Oliver E.; Oner, Sukru S.; Doluca, Osman; Cevik, Sebiha; Kaplan, Oktay Ismail (Oxford University Press, 2024)

  Uncovering the full list of human ciliary genes holds enormous promise for the diagnosis of cilia-related human diseases, collectively known as ciliopathies. Currently, genetic diagnoses of many ciliopathies remain incomplete ...

• Amelioration potential of synthetic oxime chemical cores against multiple sclerosis and Alzheimer's diseases: Evaluation in aspects of in silico and in vitro experiments 

  Yilmaz, Anil; Koca, Murat; Ercan, Selami; Acar, Ozden Ozgun; Boga, Mehmet; Sen, Alaattin; Kurt, Adnan (ELSEVIER, 2024)

  Alzheimer disease (AD) and multiple sclerosis (MS) are inflammatory neurological disorders. The main symptom of AD is dementia, and the main symptoms of MS are vertigo, sexual dysfunction, cognitive problems, and fatigue. ...

• Investigating the Impact of Birt–Hogg–Dubé Syndrome Associated Folliculin (FLCN) and Retinitis Pigmentosa 2 (RP2) Loss on Cilia Function and Morphology 

  Kaplan, Oktay İsmail (Cumhuriyet Üniversitesi, 2024)

  Folliculin (FLCN), a GTPase-activating protein (GAP), has been linked to Birt–Hogg–Dubé syndrome, the mTORC1 signaling pathway and cilia. Disruptions in cilia structure and function lead to a group of diseases known as ...

• Computational Detection of Pre-microRNAs 

  Saçar Demirci, Müşerref Duygu (Humana Press Inc., 2022)

  MicroRNA (miRNA) studies have been one of the most popular research areas in recent years. Although thousands of miRNAs have been detected in several species, the majority remains unidentified. Thus, finding novel miRNAs ...

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