Biyomühendislik Ana Bilim Dalı Tez Koleksiyonu: Recent submissions
Now showing items 1-20 of 26
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Recombinant production of GLP-1 analogue using escherichia coli host organism
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2024)Diabetes is the most serious metabolic disorder correlated with obesity, hypertensionandcardiovascular conditions. High prevalence of Type II Diabetes Mellitus (T2DM) indicatesthe need for new medication development. In ... -
Polymeric conjugates containing poegma and cystamine-modified plasmid DNAs for potential gene delivery applications
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2024)Polymer-based gene delivery systems have revealed significant advancements in the treatment of various diseases in recent years. Considering the potential of polymeric vectors, it is observed that the improvements in the ... -
Investigating the origin of the weekly cycle during the COVID-19 virus pandemic and its relation to socio-economic factors
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2024)The Covid-19 virus, which started in China in 2019 and affected the whole world, has caused a global pandemic. Looking at the worldwide data of this pandemic, the number of daily cases appears to have a weekly cycle that ... -
Determination of probiotic properties of lactic acid bacteria isolated from traditional food products
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2023)Probiotics are microorganisms that live in our bodies and positively affect health when consumed regularly. One of the ways to have a healthy body is to have a healthy microbiota. Because of that, the importance given ... -
Influence of 3D bioprinting parameters on printability and mechanical behavior of the PCL scaffolds
(Abdullah Gül Üniversitesi / Fen Bilimleri Enstitüsü, 2023)Polycaprolactone (PCL) is a synthetic polymer that exhibits desirable properties such as biodegradability, tolerable mechanical properties, and biocompatibility for a diverse range of tissue engineering applications. In ... -
Preparation and characterization of UV crosslinked alginate-based tannic acid-reinforced hydrogels
(Abdullah Gül Üniversitesi / Fen Bilimleri Enstitüsü, 2023)Alginate is a commonly used biopolymer in bioprinting applications. However, alginate-based bioinks have some mechanical limitations for printing purposes. Also, existing methacrylation methods are time consuming and have ... -
BBSome regulates ARL13B-dependent joint elongation of two distinct cilia in Caenorhabditis elegans
(Abdullah Gül Üniversitesi / Fen Bilimleri Enstitüsü, 2023)Cilia or flagella are interchangeably used to refer to the hair-like organelles extending from the cell surface to communicate with environmental signals or triggers. Cilium, the singular form of cilia, and its components ... -
Development of breast cancer targeted, multifunctional cross-linked micelle nanocarriers
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2023)In this thesis, we developed two different micelle-based nanocarriers, which are pH-responsive and core cross-linked micelle (CCMs), and specifically target HER2 receptor on breast cancer cells. Intracellularly degradable ... -
Next generation sequencing of a novel Loigolactobacillus coryniformis FOL-19 isolated from cheese and comparative genomic analysis with other L. coryniformis strains
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2023)Loigolactobacillus coryniformis is a member of lactic acid bacteria isolated from various ecological niches. We isolated a novel L. coryniformis strain FOL-19 from artisanal Tulum cheese and performed the whole-genome ... -
Cloning of 32-mer MaSP1 Gene ınto pBbB6c plasmid vector and transformation to Escherichia coli neb 10-beta
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2023)The main purpose of my thesis was to clone Masp1 spider silk protein encoding gene from dragline type spider into E.coli NEB 10-beta organism. The recombinant microbial production of spider silk protein and converting it ... -
Discovering new pathogenic variants by In silico analysis
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2022)Inherited diseases are health problems caused by one or more abnormalities in the genome. It can be caused by changes in a single gene (monogenic) or multiple genes (polygenic), or by a damage on chromosomes. Genetic ... -
Identification of single domain antibodies against SARS-CoV-2 omicron variant via protein-protein docking approaches
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2022)Omicron, became the dominant variant in 2022 in terms of spreading rate, has managed to evade from an immune system of patients due to its unique mutations. Single domain antibodies (sdAb) which are functionally important ... -
The effect of histone deacetylase inhibition and autophagy modulation on the cholangiocarcinoma cells
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2022)Cholangiocarcinoma (CCA), also known as biliary tract cancer, is a heterogeneous group of malignancies formed by the differentiation of epithelial cells in the biliary tract. CCA is the second most common primary liver ... -
IDENTIFICATION OF SURFACE PROTEOME OF B CELL ACUTE LYMPHOBLASTIC LEUKEMIA CELL LINE
(Abdullah Gül Üniversitesi / Fen Bilimleri Enstitüsü / Biyomühendislik Ana Bilim Dalı, 2022)B-cell acute lymphoblastic leukemia is characterized by over and uncontrolled expression of B lymphocytes. B-ALL may occur as a result of aberrant cytosolic signal transduction and molecular abnormalities such as gene ... -
DEVELOPMENT OF A KIDNEY TARGETTED NANOCARRIER FORMULATION AGAINST CISPLATIN INDUCED NEPHROTOXICITY
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2019)Chitosan is a natural polymer which is less toxic in the body than other synthetic polymers. Chitosan sodium tripolyphosphate (TPP) nanoparticles produced by ionic gelation method are known to be good drug delivery agents ... -
THE ROLE OF CERAMIDE METABOLISM IN APOPTOSIS TRIGGERED BY RESVERATROL AND THE THERAPEUTIC POTENTIAL OF RESVERATROL IN PH+ ACUTE LYMPHOBLASTIC LEUKEMIA
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2019)The mechanisms underlying the growth inhibitory effect of resveratrol on Ph + ALL cells were investigated with regard to targeting of ceramide metabolism and changes in BCR-ABL expression. Growth inhibition and apoptotic ... -
A BIOMIMETIC APPROACH FOR SMALL DIAMETER VESSELS: BILAYERED VASCULAR GRAFTS MADE of ALGINATE and POLY(-CAPROLACTONE)
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2019)Cardiovascular diseases (CVDs) still remain one of the leading causes of morbidity and mortality across the world. A typical symptom of CVDs is the vascular occlusion. There are many strategies for treatment such as ... -
DEVELOPMENT OF A LOW-COST MICROFLUIDIC SYSTEM TO DETECT IMMUNOMAGNETICALLY CAPTURED LEUKEMIA CELLS
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2020)Sensör teknolojileri fiziksel özellikleri ölçülebilir sinyallere dönüştürmek için kullanılır. Özellikle yarı iletken teknolojisindeki gelişmelerle birlikte, mikroakışkan olarak bilinen yeni bir teknoloji ortaya çıktı. ... -
CHARACTERIZATION OF NOVEL CILIARY GENE TMEM145
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2020)Cilia and flagella are highly conserved, microtubule based cellular structures which are found in most of the organisms. They have variety of functions from enabling movement in protozoa to signal transduction in multi ... -
THE EFFECT OF HISTONE DEACETYLASE INHIBITORS ON PTEN/PI3K/AKT/mTOR PATHWAY AND THE CARCINOGENESIS OF CHEMORESISTANT CHOLANGIOCARCINOMA AT A MOLECULAR LEVEL
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2021)Kolanjiokarsinom (CCA) agresif bir adenokarsinomdur ve ikinci en sık görülen birincil karaciğer tümörüdür. CCA gelişiminin kesin etiyolojisi hala net olarak tanımlanmamıştır. Mevcut kemoterapötik tedaviler, çoklu ilaç ...
