A horizontal magnetic tweezer for single molecule micromanipulations

Abstract

Magnetic tweezers are able to manipulate cells or biomolecules for various applications and measurements. In this work, a horizontal magnetic tweezer is designed, modeled and controlled for single molecule manipulations. A method is presented for dynamic modeling of horizontal magnetic tweezers. A linear control method is designed to ensure a wide range of operation conditions with zero steady-state error. The horizontal magnetic tweezer is able to generate a wide range of piconewton scale forces on a superparamagnetic microparticle for single molecule separation, and biosensor developments.