Gelişmiş Arama

Basit öğe kaydını göster

dc.contributor.authorIsoglu, Ismail Alper
dc.contributor.authorOzsoy, Yildiz
dc.contributor.authorIsoglu, Sevil Dincer
dc.date.accessioned2021-08-04T06:14:44Z
dc.date.available2021-08-04T06:14:44Z
dc.date.issued2017en_US
dc.identifier.issn1568-0266
dc.identifier.issn1873-5294
dc.identifier.otherPubMed ID28017154
dc.identifier.urihttps //doi.org/10.2174/1568026616666161222110600
dc.identifier.urihttps://hdl.handle.net/20.500.12573/898
dc.description.abstractThere are several barriers that drug molecules encounter in body beginning from kidney filtration and reticulo-endothelial system (RES) clearance to cellular trafficking. Multifunctional nanocarriers have a great potential for the delivery of drugs by enhancing therapeutic activity of existing methodologies. A variety of nanocarriers are constructed by different material types, which have unique physicochemical properties for drug delivery applications. Micelles formed by amphiphilic polymers are one of the most important drug/nanocarrier formulation products, in which the core part is suitable for encapsulation of hydrophobic agent whereas the outer shell can be utilized for targeting the drug to the disease area. Micelles as self-assembled nanostructures may encounter difficulties in biodistribution of encapsulated drugs because they have a tendency to be dissociated in dilution or high ionic strength. Therefore, therapeutic efficiency is decreased and it requires high amount of drug to be administered to achieve more efficient result. To overcome this problem, covalently stabilized structures produced by cross-linking in core or shell part, which can prevent the micelle dissociation and regulate drug release, have been proposed. These systems can be designed as responsive systems in which cross-links are degradable or hydrolysable under specific conditions such as low pH or reductive environment. These are enhancing characteristics in drug delivery because their cleavage allows the release of bioactive agent encapsulated in the carrier at a certain site or time. This review describes the chemical methodologies for the preparation of cross-linked micelles, and reports an update of latest studies in literature.en_US
dc.language.isoengen_US
dc.publisherBENTHAM SCIENCE PUBL LTDEXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATESen_US
dc.relation.isversionof10.2174/1568026616666161222110600en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectShell cross-linkingen_US
dc.subjectReducible micellesen_US
dc.subjectCross-linked micellesen_US
dc.subjectCore cross-linkingen_US
dc.subjectCleavable micellesen_US
dc.subjectBiodegradable micellesen_US
dc.titleAdvances in Micelle-based Drug Delivery: Cross-linked Systemsen_US
dc.typereviewen_US
dc.contributor.departmentAGÜ, Yaşam ve Doğa Bilimleri Fakültesi, Biyomühendislik Bölümüen_US
dc.contributor.authorID0000-0002-6887-6549en_US
dc.identifier.volumeVolume 17 Issue 13 Page1469-1489en_US
dc.relation.journalCURRENT TOPICS IN MEDICINAL CHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası - Editör Denetimli Dergien_US


Bu öğenin dosyaları:

DosyalarBoyutBiçimGöster

Bu öğe ile ilişkili dosya yok.

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster