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dc.contributor.authorKiraz, Yagmur
dc.contributor.authorAdan, Aysun
dc.contributor.authorYandim, Melis Kartal
dc.contributor.authorBaran, Yusuf
dc.date.accessioned2021-10-13T07:13:59Z
dc.date.available2021-10-13T07:13:59Z
dc.date.issued2016en_US
dc.identifier.issn1010-4283
dc.identifier.issn1423-0380
dc.identifier.otherPubMed ID27059734
dc.identifier.urihttps://doi.org/10.1007/s13277-016-5035-9
dc.identifier.urihttps://hdl.handle.net/20.500.12573/991
dc.description.abstractAs much as the cellular viability is important for the living organisms, the elimination of unnecessary or damaged cells has the opposite necessity for the maintenance of homeostasis in tissues, organs and the whole organism. Apoptosis, a type of cell death mechanism, is controlled by the interactions between several molecules and responsible for the elimination of unwanted cells from the body. Apoptosis can be triggered by intrinsically or extrinsically through death signals from the outside of the cell. Any abnormality in apoptosis process can cause various types of diseases from cancer to auto-immune diseases. Different gene families such as caspases, inhibitor of apoptosis proteins, B cell lymphoma (Bcl)-2 family of genes, tumor necrosis factor (TNF) receptor gene superfamily, or p53 gene are involved and/or collaborate in the process of apoptosis. In this review, we discuss the basic features of apoptosis and have focused on the gene families playing critical roles, activation/inactivation mechanisms, upstream/downstream effectors, and signaling pathways in apoptosis on the basis of cancer studies. In addition, novel apoptotic players such as miRNAs and sphingolipid family members in various kind of cancer are discussed.en_US
dc.language.isoengen_US
dc.publisherSAGE PUBLICATIONS LTD1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLANDen_US
dc.relation.isversionof10.1007/s13277-016-5035-9en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectp53en_US
dc.subjectIntrinsic/extrinsic pathwayen_US
dc.subjectBcl-2en_US
dc.subjectCaspaseen_US
dc.subjectTNFen_US
dc.subjectTRAILen_US
dc.titleMajor apoptotic mechanisms and genes involved in apoptosisen_US
dc.typereviewen_US
dc.contributor.departmentAGÜ, Yaşam ve Doğa Bilimleri Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.contributor.institutionauthorBaran, Yusuf
dc.contributor.institutionauthorKiraz, Yagmur
dc.identifier.volumeVolume 37 Issue 7 Page 8471-8486en_US
dc.relation.journalTUMOR BIOLOGYen_US
dc.relation.publicationcategoryDiğeren_US


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